In the first article of this issue published in 2008, 6 patients were treated with plasmapheresis and all of them suffered from renal failure, besides hepatic failure and after 3 plasmapheresis sessions, significant improvement in platelet, total bilirubin, creatinine, blood urea nitrogen (BUN), aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), blood sugar, prothrombin time, and hematocrit was seen [1]. This evidence concerns the gene F2 and Renal insufficiency.