So far, EH-containing proteins have not been implicated in AD; however the recognized relevance of endocytosis and trafficking of APP in the etiology of AD [82]–[84] suggests the possibility that this family of proteins, and in particular eps15 and intersectin that are highly expressed in neurons, could participate, together with the identified partners, in AD pathology via altered APP endocytosis and trafficking. The gene discussed is EPS15; the disease is Alzheimer disease.