Several of the most significant SNPs for ANM were located in/near genes previously associated with obesity, type 2 diabetes (T2D), coronary artery disease and lipid metabolism, e.g., LDLR (rs189596789), NOS1AP (rs76078015), DGKB (rs74486449), LYPLAL1 (rs78696400), and CDKAL1 (rs114158228) (Table 4). The gene discussed is LDLR; the disease is obesity due to melanocortin 4 receptor deficiency.