As with AM, to generalize results to our African American population, we examined previously identified 400 kb regions around genes associated with ANM from published candidate gene studies and GWAS: APOE, CYP1B1, CYP19A1, CYP17A1, ESR2, BRSK1, FSHB, IGF2R, PPARG, TNFSF11, TNFRSF11A, BMP15, AMHR2, TMEM224, MCM8, and IGF1 (Figure 2, Table 3) [36], [38], [58], [59], [61]–[65]. The gene discussed is APOE; the disease is nemaline myopathy 5.