When these features were analyzed for correlations, the presence of ARG2-expressing stromal cells was found to be more likely in cases with poorer tumor differentiation in terms of histological grade, presence of necrosis, and presence of stromal cells expressing CAIX and SLC2A1 (alternatively known as glucose transporter type 1, GLUT1), which are markers of hypoxia. This evidence concerns the gene ARG2 and neoplasm.