CASP3 and Hepatitis: Volarevic et al. (16) showed that IL-33/ST2 axis downregulated Con-A induced hepatitis, as supported by the evidence of more severe liver damage among ST2-deficient mice; in addition, IL-33 was reported to suppress the activation of caspase-3 and to enhance the expression of anti-apoptotic B-cell CLL/lymphoma 2 (Bcl-2) in the liver.