In addition, during BCG infection, CD11c+ cells in chronic granulomas displayed decreased expression of major histocompatibility complex (MHC) class II and co-stimulatory molecules whereas CD11c+ cells within acute granulomas could support the reactivation of recruited antigen-specific CD4+ T cells and could induce IFN-γ responses from naïve T cells (Schreiber et al., 2010). This evidence concerns the gene CD4 and Granuloma.