Consistent with its role in cellular migration and invasion, high CORTACTIN expression and/or activation has been found to associate with increased metastasis and poor clinical outcome in several types of cancer, such as renal carcinoma (Wang et al., 2009), gastric cancer (Li et al., 2008), colorectal adenocarcinoma (Cai et al., 2010), or melanoma (Xu et al., 2010). Here, CTTN is linked to cancer.