Considering the constitutive activation of LYN in MCL cells, we next evaluated the impact of PP2, a synthetic pyrazolopyrimidine selective inhibitor of SFK, and dasatinib (BMS-354825), an oral multi kinase inhibitor which also inhibits the trans-autophosphorylation of the active Tyr397 residue of LYN [30]. Here, LYN is linked to mantle cell lymphoma.