BCR and B-cell chronic lymphocytic leukemia: Constitutively active B-cell receptor (BCR)-mediated signaling has been implicated in the pathogenesis of a number of NHLs including diffuse large B cell lymphoma (DLBCL), follicular lymphoma, gastric mucosa-associated lymphoid tissue lymphoma and B-cell chronic lymphocytic leukaemia (CLL) [10-13].