Because secretion of IL-13 can influence tumor suppressor cells including myeloid derived supressor cells leading to immunoevasion [11,12], testing IL-13-PE in the immunocompetent Tgfbr1/Pten 2cKO mice will allow us to study the effects of this treatment on the tumor microenvironment, particularly the interactions with the immune system. Here, IL13 is linked to neoplasm.