Synoviocytes produce not only various matrix metalloproteinase, main effector molecules for digesting cartilages and bones, but also pro-inflammatory cytokines such as interleukin (IL)-1 and IL-6 [3], and angiogenic factors such as VEGF (vascular endothelial growth factor) [4,5], all of which play major roles in the pathogenesis of RA [6,7]. This evidence concerns the gene IL6 and rheumatoid arthritis.