Therefore, using protein array technology, we examined the changes of serum angiogenic factors, including VEGF, Ang-1, Ang-2, angiogenin, angiostatin, bFGF and PDGF-BB, and the association among these angiogenic factors, the severity of coronary artery stenosis and collateral vessels form in patients with diabetes and UAP. This evidence concerns the gene FGF2 and diabetes mellitus.