Therefore, using protein array technology, we examined the changes of serum angiogenic factors, including VEGF, Ang-1, Ang-2, angiogenin, angiostatin, bFGF and PDGF-BB, and the association among these angiogenic factors, the severity of coronary artery stenosis and collateral vessels form in patients with diabetes and UAP. The gene discussed is PLG; the disease is diabetes mellitus.