EGFR and interstitial lung disease: For instance, the incidence of the EGFR mutation is higher frequent in the Asian patients than the other origin patients and ILD induced by gefitinib occurs more frequently in Japan more than outside Japan (Ando et al. 2006; Jiang 2009; Kris et al. 2003; Kudoh et al. 2008; Park and Goto 2006; Sequist et al. 2008; Shigematsu et al. 2005; Tamura et al. 2008).