EGFR and Pleural effusion: In clinical practice of treating advanced lung cancer, specimen of the tumor by transbronchial lung biopsy or cell block of pleural effusion by thoracocentesis are occasionally insufficient or inappropriate to detect EGFR mutation (Aisner et al. 2011).The efficacy of the treatment with gefitinib may be predictable in advance, if the interaction between the skin and gefitinib in lung cancer patients can be examined before initiating therapy.