In conclusion, we report a novel case of a Ph-positive CML in the chronic phase with an absence of the ABL/BCR fusion gene on der(9) and a new complex variant Ph translocation involving the four chromosomal regions 9q34, 11p11.2, 20q11.21 and 22q11. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.