The types of cellular proteins that induce these autoantibody responses are varied and include tumor suppressors, such as p53 (5) and p16 (6), oncogene products, such as c-myc (7) and HER-2/neu (8), and other cancer-related proteins, such as Imp2/p62 (9), CRD-BP (10), CIP2A/p90 (11), survivin (12,13) and LEDGF (14). The gene discussed is ERBB2; the disease is cancer.