Because CYP2C9*2 and CYP2C8*3 variant alleles are at linkage disequilibrium (Yasar et al., 2002; Martinez et al., 2005, 2007), it could be expected that the association observed between the CYP2C9 genotypes and colorectal cancer risk (Martinez et al., 2001; Chan et al., 2004, 2009; Cleary et al., 2010; Northwood et al., 2010), could be partly related to the presence of the CYP2C8*3 variant allele. Here, CYP2C8 is linked to colorectal cancer.