It should however be emphasized that in the study population the positive association of colorectal cancer risk with CYP2C9 genotype was identified with a smaller sample size (Martinez et al., 2001) and hence, in the event that a major linkage between CYP2C8*3 and colorectal cancer risk might exist in the population studied, the sample size would be enough to identify it. This evidence concerns the gene CYP2C9 and colorectal cancer.