CAFs promote tumor infiltration and metastasis by the following possible routes: i) sectrion of a variety of growth factors including TGF-β1 and matrix metalloproteinases and participation in tumor progression (12,16,17); ii) promotion of angiogenesis (18); iii) inhibition of the body’s antitumor immunity (19,20). The gene discussed is TGFB1; the disease is neoplasm.