EGFR and Skin rash: In the EGFR mutation-negative patients, there were significant differences in TTF (P=0.0003) and survival (P=0.0009) between those with and without a rash; the median values were 1.5 months (95% CI, 31–62 days) and 5.4 months (106–245 days) in the former, and 0.7 months (12–26 days) and 2.5 months (25–102 days) in the latter, respectively (Fig. 5).