Moreover, after the U87 xenografts were injected with 2 mCi 131I, the 131I therapy retarded the Ad-GFAP-hNIS transfected-tumor growth, whereas the U87 tumors grew significantly after transfection with Ad-CMV-EGFP since they were unable to take up 131I; Fig. 5). This evidence concerns the gene GFAP and neoplasm.