Based on our results, it is possible that via the upregulation of Cyclin D1, EGFR, Bcl-2, MMP-9 and MMP-2 expression and MVD, CXCR1/2 and their ligands are involved in mediating proliferation, growth, angiogenesis, invasion and metastasis of gastric carcinoma. The gene discussed is CXCR1; the disease is gastric carcinoma.