In prostate cancer, FOXA1 genomic locus amplification was only observed in metastatic samples (Robbins et al., 2011; Grasso et al., 2012), which correlates with the observation of elevated FOXA1 staining in metastases and high grade tumors (Gerhardt et al., 2012). The gene discussed is FOXA1; the disease is Familial prostate cancer.