Grasso et al., independently discovered by exome sequencing, FOXA1 to be mutated in a single tumor from their cohort of 11 high-grade localized prostate cancers but in none of their 50 metastatic castrate resistant prostate cancers (CRPC) obtained from rapid autopsies (Grasso et al., 2012). Here, FOXA1 is linked to Familial prostate cancer.