Grasso et al., independently discovered by exome sequencing, FOXA1 to be mutated in a single tumor from their cohort of 11 high-grade localized prostate cancers but in none of their 50 metastatic castrate resistant prostate cancers (CRPC) obtained from rapid autopsies (Grasso et al., 2012). The gene discussed is FOXA1; the disease is prostate carcinoma.