Our previous study revealed that in pleural effusion from a case with ALCL, which was considered negative for ALCL by morphological examination, FCI detected a minor proportion (9.3%) of aberrant T-cell population with high FSC/SSC, a positive expression of CD4, CD7, CD2, CD45RO and CD30 and a negative expression of CD5 and CD69 (22). Here, TNFRSF8 is linked to Pleural effusion.