The only study concerning MXRA5 in relation to CRC tumorigenesis was a study by Zou et al(21), which demonstrated using qRT-PCR that the MXRA5 gene was over-expressed in CRC tissues compared with their corresponding normal tissue, and that the gene may be involved in the development and progression of CRC (21). This evidence concerns the gene MXRA5 and colorectal carcinoma.