Similarly, IAP antagonists together with TRAIL exerted antileukemic activity in a non-obese diabetic/severe combined immunodeficient (NOD/SCID) mouse model of ALL and also acted in concert to trigger apoptosis in ALL cell lines as well as in primary blasts obtained from children with ALL (Fakler et al., 2009). Here, TNFSF10 is linked to acute lymphoblastic leukemia.