Soluble TRAIL as well as TRAIL receptor 2 agonistic antibodies were shown to trigger apoptosis in primary neuroblastoma cells, in particular in combination with molecular targeted therapeutics, i.e., Smac peptides, IAP antagonists, or proteasome inhibitors (Fulda et al., 2002b; Naumann et al., 2011; Abhari et al., 2012). Here, TNFSF10 is linked to neuroblastoma.