TNFSF10 and neuroblastoma: In order to target the two proapoptotic TRAIL receptors, soluble TRAIL as well as antibodies directed selectively against TRAIL receptor 1 or TRAIL receptor 2 have been reported to elicit apoptosis in childhood malignancies, e.g., in neuroblastoma, rhabdomyosarcoma, Ewing’s sarcoma and leukemia (Petak et al., 2000; Van Valen et al., 2000; Kontny et al., 2001; Fulda et al., 2002a; Ehrhardt et al., 2003; Yang and Thiele, 2003; Fulda, 2008; Kang et al., 2011; Abhari et al., 2012).