Among the 49 PRC2 targets (defined by consistent hyper-MVPs) identified here were 10 genes of the cadherin superfamily in HPV+ HNSCC, including CDH8 and CDH13 (both also hypermethylated in cervical cancer [64], CDH18, CDH19, CDH23, PCDH10, PCDH15, PCDHB1, PCDHB4, and PCDHB15. The gene discussed is PCDHB4; the disease is head and neck squamous cell carcinoma.