Among the top 10 anti-correlated (high promoter methylation and low expression) genes were three of the cadherins, namely CDH8, PCDH10, and PCDHB11. The inverse scenario (low promoter methylation and high expression) was also found, and both are likely to contribute to the different clinical behavior of HPV+ and HPV- HNSCC with regard to survival and response to therapy. Here, CDH8 is linked to head and neck squamous cell carcinoma.