Similarly, STAT3, an important member of the JAK-STAT pathway, is activated by both EGF and cytokines (IL-10, IL-6), and has been proposed to play a central role in viral-induced HCC [27], where IL-6 and EGF were shown to act in concert to promote expression of HBV viral genes [28]. The gene discussed is EGF; the disease is hepatocellular carcinoma.