Consistent with a role of high-level expression of PRL-3 in metastasis, we demonstrated that ectopic expression of PRL-3 in Chinese hamster ovary cells enhanced motility, invasive activity and induced metastatic tumor formation in mice [11], suggesting that elevated expression of PRL-3 phosphatase may be a key contributor to the metastasis of the transformed cells. Here, PTP4A3 is linked to neoplasm.