MAPK1 and acute pancreatitis: In previous studies, we have characterized in detail various aspects of the new experimental model of ligation-induced acute pancreatitis in mice developed in our laboratory.[2], [3], [27] We demonstrated a near-100% mortality in this model, with 75% of mice dying between day 2 and day 4, and median survival of 3 days.[3] Activation of ERK was seen in the pancreas, lung, liver and kidney.