IL33 and acute pancreatitis: Our studies have resulted in the novel findings that the IL-33 concentration is increased in the pancreas in ligation-induced acute pancreatitis, IL-33 is released from isolated pancreatic acinar cells following agonist stimulation, IL-33 activates proinflammatory pathways in pancreatic acinar cells in vitro and in vivo, and that IL-33 exacerbates acute pancreatic inflammation.