The 2005 discovery of IL-33 as a new member of the IL-1 superfamily of cytokines has stimulated considerable scientific interest about its potential role in the progression of several inflammatory conditions.[4], [13], [14] In 2010, four independent groups discovered the association between IL-33 expression and human ulcerative colitis.[6], [16]–[18] However, investigations into the role and expression of IL-33 in acute pancreatitis are limited.[20] Ouziel et. This evidence concerns the gene IL33 and acute pancreatitis.