As the elucidation of the important events in the early stages of disease progression in humans is not possible, we characterized a novel mouse model of pancreatic duct ligation-induced acute pancreatitis that is associated with systemic inflammation and substantial mortality.[2], [3] The primary objective of the present study was to examine the potential role of the novel cytokine interleukin-33 (IL-33) in the pathogenesis of acute pancreatitis. Here, IL33 is linked to acute pancreatitis.