It has been reported that memory T cells obtained from the pleural fluid were shown to express a battery of homing receptors, including CCR5, which mediated adhesion of T cells from TB-PEs to activated human umbilical vein endothelial cells (HUVEC) expressing chemotactic ligands, which suggested the important role of CCR5 in the polarization of Th1 cells. The gene discussed is CCR5; the disease is tuberculosis.