Though the biological activity of CCL8/MCP-2 in mice remains unclear, recent report showed that CCL8/MCP-2 in plasma increases with incidence of Graft-Versus-Host-Disease(GVHD) which is a complication of bone-marrow transplantation and the study suggests that MCP-2/CCL8 is associated with immune response within a living organism of mouse [39], [40]. Here, CCL8 is linked to graft versus host disease.