Interestingly, this down-regulation of HLA-G in the treated infected cells was observed at 36 and 60 hr post infection and then HLA-G expression was up-regulated compared with the untreated infected group; this is consistent with the data that indicates that IL-10 induces HLA-G expression [19] and with results of our study in vivo[4]. The gene discussed is IL10; the disease is infection.