The striking downregulation of retinol-binding protein 4 (RBP4) mRNA to <10% of Uremic group levels in both PD and EPS groups has been associated with lean body mass [63] and with ovarian cancer [64], but impaired glucose tolerance and obesity were associated with elevated serum RBP4. Here, RBP4 is linked to obesity due to melanocortin 4 receptor deficiency.