However, we find the ckit mRNA associated with all four Ago proteins together with miR-18b, which is lower expressed in t(8;21)- positive leukemia in our pediatric cohort relative to other cytogenetic subtypes but also relative to the examined adulthood t(8;21) patients (∼70-fold, p = 0.003). Here, FBXW7 is linked to leukemia.