Remarkably, the hierarchical clustering of Ago-associated mRNAs showed also a complete separation of both cell lines indicating that each Argonaute protein works together with distinct subsets of miRNAs in order to regulate certain mRNAs differing between the KASUMI-1 AML cell line model with t(8;21) and the NB4 APL cell line model. This evidence concerns the gene FBXW7 and acute myeloid leukemia.