SHH and cancer: Finally, we found that PBOV1 expression in both GDS1746 [37] prostate and GDS806 [35] breast cancer datasets was highly correlated to the expression level of sonic hedgehog (SHH) (0.50, p = 0.002, 8.1th percentile and 0.60, p = 2•10−7, 1.0st percentile, respectively), indicating that the Hedgehog pathway could be one of the drivers of PBOV1 activation in those cancer types.