CAMK2N1 and brain neoplasm: In addition, increased expression of calcium/calmodulin-dependent protein kinase 1 (CAMK1, 2.6-fold) and calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1, 2.1-fold) that results in alteration of calcium homeostasis may also contribute to the change of neuronal excitability and the frank epileptiform discharges [37], [38] associated with brain tumors.