We analyzed 914 cancer cell lines in the Novartis cell line encyclopedia (CLE) [23], in which copy numbers and mutations of SnoN and p53 genes were characterized using Affymetrix SNP6 microarray or RNAseq technology, to determine whether samples with increased copy number of the SnoN gene also tend to show inactivation of p53 as indicated by a loss of p53 copy number or the presence of known inactivating mutations. This evidence concerns the gene TP53 and cancer.