SKIL and neoplasm: Grade III tumor stroma, however, showed a significant upregulation of SnoN expression than grade I tumors (p = 0.0068), reaching a level similar to and in 55% of the samples, higher than that in normal tissues (last panel, Figure 2A), especially in infiltrating fibroblasts and inflammatory cells (lymphocytes, leukocytes and phagocytes) (Figure 2A and 2C).