Interestingly, although in any individual cell in the DCIS tissues, the level of SnoN expression was similar to or in a few cases, lower than that in cells in normal tissues, due to a markedly increased epithelial content in DCIS samples, the overall SnoN level in the whole tissue was much higher than that in normal tissues (Figure 5D). This evidence concerns the gene SKIL and ductal breast carcinoma in situ.