These DAPC-associated myopathies affect skeletal muscles but are also associated with cardiac dilation to a variable degree, ranging from only rare and mild symptoms in LGMD2D patients [28] and mouse model [29] to more pronounced cardiac pathology in LGMD2C and DMD patients and mouse models [30]. The gene discussed is SGCG; the disease is autosomal recessive limb-girdle muscular dystrophy type 2D.