EGFR and non-small cell lung carcinoma: Taniguchi et al [31] analyzed the relationship between EGFR heterogeneity and the response to EGFR-TKIs by microdissection in early-stage NSCLC tumors, and reported that patients with a greater EGFR mutation frequency were more sensitive to EGFR-TKIs and showed longer progression-free survival times than patients with low EGFR mutation rates.