Tau immunostaining of hippocampus and frontal cortex (the two main brain regions displaying pathology in AD brains and animal models) failed to reveal any staining in paraffin-embedded, fixed tissue from compound Trp73+/- + TgCRND8 mice, either at (45-60 days old) or after (70 days old) the ages reported by Wetzel et al. (Figure 2A and Additional file 2: Figure S2). Here, MAPT is linked to Alzheimer disease.