In practice, though using the same APP transgene and the same Trp73 null allele, we have not been able to demonstrate AD-like tau pathologies in compound mutant mice, nor in Trp73 haploinsufficent mice of comparable ages to those described by the Wetzel et al. study, nor in mice homozygous null for DeltaNp73. Here, MAPT is linked to Alzheimer disease.