TP73 and Alzheimer disease: Li et al. also reported an allelic expression bias for p73 only in a single control brain (not in AD samples) and that the allele weakly associated with AD did not change the promoter activity of TP73. Scacchi et al.[39] tested association of AD with four TP73 SNPs, including two (rs227395 and rs1801173), which form a putative functional haplotype, another in the promoter region (rs3765728) and a synonymous coding SNP (rs1801174).