In addition to identifying a remarkable number of direct interactions between LGMD proteins, mining the data revealed that LGMD proteins belong to a highly connected network of interacting proteins with, in particular, the sarcomeric proteins ACTN2, MYBPC1, MYOM1 and MYOM2 identified as hub proteins sharing the highest number of links with the LGMD proteins. Here, ACTN2 is linked to limb-girdle muscular dystrophy.