Although the precise underlying mechanism remains to be determined, in vitro we found that the HCC cell lines with highly metastasis potential, especially MHCC-97H and MHCC-97 L [44], had a relatively high MACC1 and c-Met expression, whereas suppressing of MACC1 by si-RNA significantly reduced c-Met expression. The gene discussed is MACC1; the disease is hepatocellular carcinoma.