Moreover, the advanced HCC patients with MACC1 nuclear staining had a poorly CER and DCR than those with MACC1 cytoplasmic staining (12.8% vs. 16.7%, p = 0.843 for CER; 43.6% vs. 68.8%, p = 0.0321 for DCR). Here, MACC1 is linked to hepatocellular carcinoma.