VDR and nevus: According to HapMap, rs7975218 is in complete LD (r2 = 1) with VDR functional variants BsmI and TaqI (rs731236) which formed a block in tight LD, including also ApaI (rs7975232), located at the 3’UTR region of VDR. Consistent with previous findings in melanoma where, both TaqI and BsmI have been shown to be protective against melanoma risk[21-23], SNP rs7975128 showed a protective tendency for high nevus number and number of melanoma.