Reduced expression of different death receptors is also one of the crucial mechanisms of the resistance of glioblastoma to apoptosis.28 It can occur via mutated p53 pathway, which is the most commonly mutated pathway in tumorigenesis, and is strongly connected to apoptosis and necroptosis as well.28,29 Furthermore, mutation of human rat sarcoma (RAS) genes is also frequently associated with glioblastoma tumorigenesis. Here, TP53 is linked to glioblastoma.