Another recent evaluation concerning the risk of recurrence for small node-negative breast cancer by age and tumor subtypes showed that, after adjusting for subtype and other tumor characteristics, patients ≤35 years had greater risk of worse RFS compared to patients older than 50 years and confirmed the unfavorable outcome of Her-2 positive and triple negative T1a and b tumors (Theriault et al. 2011). This evidence concerns the gene ERBB2 and neoplasm.