In the last years, TNM staging, Her-2 and hormonal receptor status, tumor grading, and lymphovascular invasion have been routinely considered in stage I breast cancer treatment decision, but, unfortunately, there is no general agreement on the magnitude of benefit from adjuvant systemic treatments, and clear guidelines are lacking in this patient subset (McArthur et al. 2011; Kwon et al. 2010; Ho et al. 2012; Amar et al. 2010). The gene discussed is NR4A1; the disease is breast cancer.