We also observed down-regulation of p-Wee1 (Ser642) and Myt1 in Hey and SKOv3ip cells, indicating that the efficacy of Corilagin in inducing G2/M arrest in ovarian cancer cells is possibly due to the down-regulation of cdc2 and Cyclin B1 through Wee1 and Myt1 regulation. The gene discussed is WEE1; the disease is ovarian cancer.