However, compared to those without depression, individuals with depression had significantly higher CRP levels (4.1(1.9-7.6) vs 1.5(0.5-4.4) mg/l; p = 0.02; Mann Whitney test) and 24-hour urine free cortisol (71.4 ± 21.3 vs 59.8 ± 29.3 ug/24 h; p = 0.03; Mann Whitney test). This evidence concerns the gene CRP and major depressive disorder.