Several biological alterations have been reported in individuals with depressive disorders that might increase the risk for type 2 diabetes, including activity of the hypothalamic-pituitary-adrenal (HPA) axis leading to hypercortisolism, sympathetic nervous system (SNS) activation, increases in C-reactive protein (CRP) and inflammatory cytokines as tumor necrosis factor (TNF)-alpha and interleukin (IL)-6, and alterations in norepinephrine and serotonin metabolism [4-8]. This evidence concerns the gene TNF and depressive disorder.