When we included the combination of high CRP and high NLR as a variable into the analysis, the combination of CRP and NLR (p < 0.001; HR 1.905; 95% CI 1.345–2.697) together with Child-Pugh class (p < 0.001; HR 1.806; 95% CI 1.464–2.228), tumor size > 5 cm (p = 0.002; HR 1.858; 95% CI 1.258–2.743), presence of PVT (p < 0.001; HR 1.893; 95% CI 1.329–2.697) and AFP > 200 ng/mL (p < 0.001; HR 1.821; 95% CI 1.324–2.504) were identified as independent factors for worse survival instead of CRP or NLR alone. The gene discussed is CRP; the disease is neoplasm.