Compared to mock-treated cells, stimulation of myocytes with 0.3 nM ET-1, or trypomastigote infection over a 24-h period, or the combination of both, induced a significant production of COX metabolites, mainly TXB2, the stable metabolite of TXA2, and prostaglandins E2 (PGE2) and PGF2α. The gene discussed is EDN1; the disease is infection.