Circulating Ang-2 levels were not significantly different between healthy children and those with pre-dialysis CKD, but were markedly and significantly increased in the dialysis group (means±SD in controls 2.7±1.2, pre-dialysis CKD 2.7±0.9, dialysis 10.5±6.9 ng/ml, p<0.0005 in comparisons between dialysis patients and both the other groups). Here, ANGPT2 is linked to chronic kidney disease.