PWV was increased in two out of 14 children with pre-dialysis CKD (5.1±0.2 m/sec in pre-dialysis CKD versus 5.0±0.3 m/sec in controls) and 7 out of 24 (5.6±0.5 m/sec) on dialysis but did not show any correlation with Ang-2 in either group. The gene discussed is ANGPT2; the disease is chronic kidney disease.