ENSG00000279284 and neoplasm: Agrawal et al [20] discovered in a whole exome sequencing study of a series 32 primary head and neck squamous cell tumors that nearly 40% of the 28 mutations identified in Notch1 were predicted to truncate the gene product, and they suggest that Notch1 may function as a tumor suppressor gene rather than an oncogene in this tumor type.