Multiple lines of evidence suggest a role for the inflammasome in NASH, for example, IL-1 receptor (IL-1R) is thought to play a role in NASH since IL-1 knockout and IL-1R knockout mice are protected from methionine and choline deficient (MCD) diet-induced steatohepatitis [17], [18], [19], [20]. Here, IL1R1 is linked to metabolic dysfunction-associated steatohepatitis.