HIF-1α overexpression was observed in 63% (20/32) of the BRCA1, in 62% (10/16) of the BRCA2 and in 34% (26/77) of the non-BRCA mutation-related DCIS cases (p = 0.005;Table 1). The gene discussed is BRCA2; the disease is ductal breast carcinoma in situ.